Kiran Krishnan on Instagram: "Gut-derived endotoxins, LPS (lipopolysaccharides), directly drives anxiety and depression. When we have gut dysbiosis and intestinal permeability (leaky gut), LPS leaks into circulation and induces an inflammatory cascade that crosses the blood-brain barrier. When cytokines triggered by LPS reach the central nervous system, they activate microglia, the brain’s immune cells, to create neuroinflammation. This disrupts neurotransmitter balance, decreasing serotonin and