Rationale for modification 1. In the early 2000s, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group developed a framework in which the certainty in evidence was based on numerous factors and not solely on study design which challenges the pyramid concept.8 Study design alone appears to be insufficient on its own as a surrogate for risk of bias.

4 days ago · BMJ Evidence-Based Medicine (BMJ EBM) publishes original evidence-based research, insights and opinions on what matters for health care. We focus on the tools, methods, and concepts that are basic and central to practising evidence-based medicine and deliver relevant, trustworthy and impactful evidence.

Introduction. To highlight and advance clinical effectiveness and evidence-based practice (EBP) agendas, the Institute of Medicine set a goal that by 2020, 90% of clinical decisions will be supported by accurate, timely and up-to-date clinical information and will reflect the best available evidence to achieve the best patient outcomes.1 To ensure that …

External validity is a construct that attempts to answer the question of whether we can use the results of a study in patients other than those enrolled in the study. External validity consists of two unique underlying concepts, generalisability and …

Vaccination is a life-saving endeavour, yet risk and uncertainty are unavoidable in science and medicine. Vaccination remains contentious in the public mind, and vaccine hesitancy is a serious public health issue. This has recently been reignited in the discussion over potential side effects of COVID-19 vaccines, and the decision by several countries …

Oct 8, 2024 · Clinical practice guidelines, commonly referred to as ‘guidelines’, play an important role in guiding physicians in their clinical practice by bridging the gap between research evidence and healthcare decisions.1 However, the current guidelines face challenges such as varying quality levels, poor clinical applicability and difficulties in implementation.2 3 To solve the these problems, the ...

Dissemination has been defined as ‘the targeted distribution of information and intervention materials to a specific public health or clinical practice audience’,1 and as being ‘simply about getting the findings of your research to the people who can make use of them, to maximise the benefit of the research without delay’.2 Ethics guidelines concur that …

Methods A literature search was performed in PubMed, Scopus, PsycInfo and Google Scholar up to 2 June 2023 to identify guidelines for the development and validation of PROMs. Screening of records and reports as well as data extraction were performed by two reviewers. To assess the comprehensiveness of the included guidelines, a mapping synthesis was performed and steps to develop and validate ...

Objectives To systematically collect and analyse diverse definitions of ‘evidence’ in both health and social sciences, and help users to correctly use the term ‘evidence’ and rethink what is the definition of ‘evidence’ in scientific research. Design Scoping review. Methods Definitions of evidence in the health sciences and social sciences were included. We have excluded the ...

Dickersin and Min define publication bias as the failure to publish the results of a study ‘on the basis of the direction or strength of the study findings’.1 This non-publication introduces a bias which impacts the ability to accurately synthesise and describe the evidence in a given area.2 Publication bias is a type of reporting bias and closely related to dissemination bias, although ...