During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

imageimageThis study developed a systematic workflow leveraging transcriptomics and metabolomics to identify input signals for 41 transcription factors in E. coli. A systematic workflow was developed ...

Xenobiotics like drugs are recognised as key influencers of gut bacterial growth. Yet, their impact on the production of metabolites involved in microbiota–host interactions is largely unknown. Here, ...

De novo protein design is of fundamental interest to synthetic biology, with a plethora of computational methods of various degrees of generality developed in recent years. Here, we introduce ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study presents and characterizes a Dnmt3a ...

This study explores how mechanical signaling through membrane tension induces somal translocation during neuronal migration.

How loss of KIF4A chromokinesin reduces chromosome association of condensin has remained unclear. This study demonstrates that human condensin I is auto-inhibited by short linear motifs (SLiMs) in its ...

imageimageDysregulated neutrophil activation plays a significant role in sepsis. This study shows that the membrane protein CMTM3 is upregulated in sepsis and critically regulates neutrophil migration ...

We report the development and proof-of-concept of a novel transient CAR Tcell system that can be conditionally armed with recombinant VAR2CSA lectins (VAR2) to target oncofetal CS glycans on tumor ...