Glycogen, a hyperbranched polymer of glucose, plays a central role as an energy reserve across diverse organisms. In Escherichia coli, its biosynthesis is linked not only to energy storage but also to ...

A surprising discovery about how brain cells handle sugar could shift how scientists approach dementia and Alzheimer’s treatments. In a new study published in Nature Metabolism, researchers uncovered ...

A new study from scientists at the Buck Institute for Research on Aging has revealed a surprising player in the battle against Alzheimer's disease and other forms of dementia: brain sugar metabolism.

Phosphatidylinositol 3-kinases (PI3Ks) are a family of enzymes that catalyze the phosphorylation of phosphatidylinositol at the D-3 position of the inositol ring, serving critical functions in ...

In a scientific first, researchers from Vanderbilt University and the University of California, San Diego, have generated a high-resolution metabolic "map" of how cells orchestrate glucose processing, ...

In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia Buck Institute for Research on Aging A new study from ...

In a new study published in Nature Metabolism titled “Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction,” researchers from the Buck ...

Gerty Theresa Cori (1896-1957) was a trailblazing biochemist whose work fundamentally reformed our understanding of how cellular energy is stored and released in the body. 1 In 1947, she became the ...

A new Yale study has revealed that neurons — the energy-hungry cells that connect and direct activity in the brain — are equipped with “backup batteries” that kick in to keep the brain running during ...

Gerty Cori was a biochemist whose work fundamentally reformed our understanding of how cellular energy is stored and released in the body. Despite facing systemic barriers as a Jewish woman in ...