Tennessee lost 37-24 to the San Francisco 49ers on Dec. 14 at Levi's Stadium, with the 49ers scoring on their first five drives and seven of eight possessions overall. Brock Purdy threw for 295 yards and three touchdowns, while Murfreesboro's Jauan Jennings caught two touchdown passes.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

The 49ers are 12.5-point favorites, per the latest Titans vs. 49ers odds, and the over/under for total points scored is 44.5 at DraftKings. The 49ers are -901 money line favorites (risk $901 to win $100),