E1 enzymes activate ubiquitin (Ub) and ubiquitin-like (Ubl) proteins in two steps by carboxy-terminal adenylation and thioester bond formation to a conserved catalytic cysteine in the E1 Cys domain.

Polymers with covalent cross-links, once formed, cannot generally be reshaped, remolded, or deformed, which is attractive for creating robust materials but these properties can also severely limit ...

Researchers demonstrated how amino acids could spontaneously attach to RNA under early Earth-like conditions using thioesters, providing a long-sought clue to the origins of protein synthesis. This ...

Here’s what you’ll learn when you read this story: In the beginning, there were prebiotic compounds that were the ingredients for life but had not yet come together in the right ways. Organic sulfur ...

Chemists at University College London have shown how two of biology's most fundamental ingredients, RNA (ribonucleic acid) and amino acids, could have spontaneously joined together at the origin of ...

Thioester, Acylmercaptan, eine Verbindung der allgemeinen Formel RS~CO-R1. Die Thioester- (Acylmercaptan-) Bindung ist energiereich. Ein T. ist z.B. das Acetyl-Coenzym A als Prototyp einer aktivierten ...

Thioester, Acylmercaptan, eine Verbindung der allg. Formel RS-CO-R 1. Die Thioester-Bindung ist energiereich. Ein T. ist z.B. das Acetyl-Coenzym A als Prototyp einer aktivierten Fettsäure. Bei der ...