In amyotrophic lateral sclerosis and many cases of frontotemporal dementia, the RNA-binding protein TDP-43 abandons the nucleus and clumps up in cytoplasm, disrupting the normal workings of neurons ...
Cells, are you experiencing stress? Quick, SUMOylate your TDP-43 before it’s too late! Three independent papers appearing in rapid succession deliver the same message: Chain the small ubiquitin-like ...
Neurodegenerative diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are medical conditions characterized by the progressive degradation ...
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