Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the ...

Scientists have decoded for the first time the “stability blueprint” of an enzyme that resides in a cell’s membrane, mapping which parts of the enzyme are important for its shape and function. These ...

Integral membrane proteins rule the border between the cell and the outside world. They mediate diverse forms of communication and transport across the membrane, develop intimate contacts with the ...