The production of biotherapeutics involves many unit operations, and it is common practice to store in-process material as dictated by the manufacturing setup and scheduling of unit operations. The ...

Monoclonal antibody expression systems typically utilise a signal peptide to ensure secretion of the antibody into the cell culture medium. Although this reduces the complexity of purification and ...

Upstream titers of 3–5 g/L, and up to 10–13 g/L, are outpacing downstream capacity, creating chromatography, filtration, and UF/DF throughput bottlenecks that elevate cost and delay timelines. Complex ...

Efforts to raise protein-expression levels have succeeded mightily, but at a cost. Today, high protein titers and accompanying impurity levels have come to dominate downstream processing. “We have ...

The long journey from cell culture to a purified monoclonal antibody (mAb) involves many sample processing steps, with clarification and filtration playing significant roles. However, clogs, complex ...

Monoclonal antibodies (mAbs) are an important class of therapeutics. In recent years, however, increased attention has been devoted to the development of next-generation biologic therapeutics and ...

WESTBOROUGH, MASSACHUSETTS, June 24, 2020 — Pall Laboratory, a global leader in proven filtration, separation and sample preparation solutions, has introduced two AcroPrep™ 24-well filter plates. The ...

A novel method to improve the high-yield, high-purity, high-activity purification of complex proteins by 10- to 500-fold has been developed at the University of Alabama at Birmingham. “This new method ...