Week 6 begins on Thursday night with a fascinating interconference showdown between the defending champion Seattle Seahawks and the Denver Broncos. Then, on Sunday, Caleb Williams is likely to make his return to the field as the Bears take on a resurgent Atlanta Falcons team.

In Week 6 of the 2026 NFL season, the model is not confident in the 3-2 Pittsburgh Steelers, who are 2.5-point and -139 money-line favorites at the best betting apps against the one-win Buccaneers at Raymond James Stadium in Tampa, Fla., on Sunday at 1 p.m. ET.

After a cinematic Monday Night Football game between the Los Angeles Rams and Buffalo Bills, Bleacher Report's expert crew feels refreshed, especially since most of the panel nailed the pick.

Aaron Rodgers is having a tidy revival, throwing three touchdown passes in each of his last three games. Even better, he did it without Michael Pittman or Roman Wilson in the lineup for Week 5. But the Steelers aren't in the circle of trust yet...

David Fucillo makes picks for all 14 NFL games with levels of confidence ahead of Week 6. The NFL is back for Week 6 as the playoff picture slowly starts to gain some clarity. The playoff push heats up closer to Thanksgiving, but we’re starting to see teams position themselves for a run or reach a point where rebuilding might be in order.

Every Sunday, Kevin Cusick makes his predictions against the latest Las Vegas point spread, the way God intended

SportsLine's model enters Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. One of its favorite picks at the best betting apps is the Cardinals (+12.5, 51.5) covering versus the Rams, which cashes 56% of the time. You can find the model's picks for every NFL Week 6 game here.