The Week 5 NFL schedule features a compelling slate of matchups across the league, highlighted by several key games that could help shape the NFL playoff picture. The Dallas Cowboys (-1.5, 47.5) will take on the New York Jets,

The Week 4 NFL schedule has a number of key matchups, including eight interconference matchups. The season's biggest NFL spread takes place in

Anyone who thought they had football figured out within the first month of the 2025 season probably doesn't feel that way going into NFL Week 5 now. If you were

SportsLine's model evaluated the Week 3 NFL odds and revealed its NFL predictions, NFL score predictions and NFL betting picks for every game

There are lots of slim Week 5 NFL spreads to make NFL picks on, as only three contests have a line of more than a touchdown. The outliers are

Favorites are still winning at a high clip in the NFL, but we saw at least a couple of upsets last week. Both the Los Angeles Chargers and Dallas Cowboys won as

Fading Indianapolis may also be part of a greater NFL survivor pool strategy, which sees the Colts play a struggling Titans team in a couple of weeks. The model projects the Colts to win 75% of the time, which is lower than other teams this week, making Indianapolis a team to avoid in NFL survivor pool picks. See which team to pick instead here .

Some of the site's predictions differ from NFL Week 5 odds and other NFL Week 5 picks for NFL Week 5 games. How correct will the analytics be this week? Click on each game for more NFL Week 5 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

The Kansas City Chiefs and Jacksonville Jaguars meet at EverBank Stadium in Jacksonville, Florida, for a Sunday Night Football matchup.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.