The breakdown of methylmalonic acid yields fatty acids necessary for the formation of myelin. Has anyone measured the level of methylmalonic acid in demyelinating diseases, such as multiple sclerosis ...

Genomic methods, specifically whole exome and whole genome sequencing, have been at the center of diagnosing rare, genetic diseases. For example, diagnosing the inborn errors of metabolism (IEM) ...

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Methylmalonic acid (MMA) buildup has recently been suggested to contribute to the onset of both ...

TAMPA, Fla. (Oct. 31, 2024) — A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which ...

Cancer cells can disrupt a metabolic pathway that breaks down fats and proteins to boost the levels of a byproduct called methylmalonic acid, thereby driving metastasis, according to new research. The ...

A recent study from UiB shows that elevated plasma methylmalonic acid predicts increased risk of acute myocardial infarction and mortality in patients with suspected or verified coronary heart disease ...

Methylmalonic acidemia and cobalamin deficiencies represent a group of inborn errors of metabolism that arise from impaired processing of vitamin B12 (cobalamin). This impairment often results in the ...

The U.S. Food and Drug Administration (FDA) has lifted the clinical hold on LogicBio Therapeutics’ LOGC Investigational New Drug Application (IND) of its drug candidate LB-001 for pediatric patients ...