The helicase unzips the double-stranded DNA for replication, making a forked structure. The primase generates short strands of RNA that bind to the single-stranded DNA to initiate DNA synthesis by the ...
Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...
On their own, however, polymerases aren't good at staying on the DNA strand. They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand, and ...
Failures in DNA replication can lead to cancer, birth defects or other harm Video shows single pieces of double-helix DNA being copied Single-molecule view gives new insights into this process ...
DNA polymerase (pol) δ is essential for both leading and lagging strand DNA synthesis during chromosomal replication in eukaryotes. Pol δ has been implicated in the Okazaki fragment maturation process ...
For the first time ever, scientists have captured a single DNA molecule replicating on video — and it’s changing the way we think about the entire process. One of the most surprising findings is how ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...
For the first time ever, scientists have captured a single DNA molecule replicating on video — and it’s changing the way we think about the entire process. One of the most surprising findings is how ...
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