The San Francisco 49ers resume their quest for the No. 1 seed in the NFC West - yes, seriously - by facing the Tennessee Titans, who are tied for the worst record in the NFL.

It wasn’t a pretty first half, but the San Francisco 49ers bounced back to blow out the Cleveland Browns in Week 13.

The Indianapolis Colts made it official: quarterback Philip Rivers is back in the NFL, signing with the team's practice squad. That move sets up a likely Week 16 showdown between the 44-year-old veteran and the San Francisco 49ers defense when the Niners travel to Lucas Oil...

In an interview with our sister network ESPN, San Francisco 49ers receiver Ricky Pearsall says he was unsure of his fate after he was shot in the chest during an armed robbery last year near San Francisco's Union Square.

The 49ers running back topped 100 yards from scrimmage for the 10th time this season to make up for his quarterback's three interceptions.

The NFL has announced its 26 modern-era semifinalists for the Pro Football Hall of Fame's Class of 2026, and former San Francisco 49ers running back Frank Gore is among the notable names. This marks Gore's first year of eligibility, positioning the legendary rusher one step...

Cleveland Browns quarterback Shedeur Sanders made his first NFL start in Week 12, eclipsing the 200-yard mark with a touchdown

The San Francisco 49ers and Cleveland Browns will meet on Sunday at Huntington Bank Field. Here's who experts think will win the Week 13 battle.