The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

During the American Diabetes Association national conference this year in Philadelphia, scientists gathered to discuss recent advances in this field at a session on positive and negative elements in ...

The insulin and the IGF-1 pathway are closely intertwined. Both can bind the insulin receptor or the IGF receptor 1 (IGFR-1). IGF-2, on the other hand, can bind either IGFR-1 or the high-affinity IGFR ...

Obesity has become a global epidemic affecting diverse populations and leading to metabolic syndrome across different sexes and age groups. A significant aspect of obesity is the development of leptin ...

Three years ago, the inceptor protein was discovered and its role as an inhibitor of the insulin signaling pathway was described. Inceptor and the insulin receptor are located on the surface of beta ...

WEHI researchers in Melbourne have answered a 100-year-old question in diabetes research: can a molecule different to insulin have the same effect? The findings provide important insights for the ...

Evidence is growing that insulin resistance drives Alzheimer’s disease development, and several medications used to treat diabetes are in clinical trials to see whether they can combat the condition.

Frederic Calon has received funding from: Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), Fonds de la recherche du Québec en santé ...

A deep dive into the scientific shift toward multi-target obesity therapeutics and its implications for metabolic health and disease prevention.