For patients with higher-grade or progressive IDH -mutant glioma, how do you individualize choice between radiotherapy (RT) ...

Inside the cell nucleus, DNA strands wrap around spool-like proteins called histones. How DNA is spooled can ultimately influence how and when genes get made into proteins. Summary MSK researchers ...

BEIJING, Aug. 22, 2018 /PRNewswire/ -- Recently, a review paper on the "Biological Role and Therapeutic Potential of IDH Mutations in Cancer" was published in Cancer Cell, the authoritative ...

A diagnosis of glioma, a particularly aggressive form of brain cancer, is never one that oncologists want to deliver. But not all gliomas are created equal. Those with mutations in a gene known as IDH ...

This drug is for previously untreatable low grade IDH-mutant glioma, the most common malignant primary brain tumor in adults. This is the first major advance in decades for patients diagnosed with low ...

We have determined IDH1/2 mutations in localized prostate cancer (PCa), which has significant heterogeneity in genomic stability, tumor metabolism and clinical outcome. 3 Mutational and array ...

IDH inhibitors, now FDA approved for lower-grade gliomas, yield fewer side effects than chemotherapy, said Dr. Ryan Merrell. IDH inhibitors are now approved by the Food and Drug Administration (FDA) ...

(Medical Xpress) -- Three research teams have published papers in Nature, that together offer evidence suggesting that isocitrate dehydrogenase (IDH) enzyme mutations may play a role in altering ...

Gliomas are the most common brain tumors, and many start off growing slowly as “low-grade” tumors before inevitably becoming aggressive, lethal, and “high grade.” New research offers an explanation ...