For gout, xanthine oxidase (XO) inhibitors are the choice for first-line urate-lowering therapy (ULT) according to the 2020 American College of Rheumatology Guideline for the Management of Gout, which ...
A small study tied specific human leukocyte antigen (HLA) class I alleles to a higher risk for allopurinol-induced severe cutaneous adverse reactions (SCARs) in the US.
The prescribed dosage for allopurinol may vary depending on a person’s individual treatment plan. Factors such as your medical history and body weight may also affect your dosage of allopurinol.