Iran and Israel targeted each other with airstrikes early on Saturday after Israel launched its biggest-ever offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.

President Trump joked that Iranian officials killed in Israel's airstrike clearly did not die of an illness, warning that Iran should have heeded his warning.

The attack was a stiff challenge for Israel’s air-defense system, which has intercepted projectiles fired from Gaza, Lebanon, Syria, Iraq, Yemen and Iran since the start of the war Oct. 7, 2023. They have ranged from short-range rockets to medium-range missiles to attack drones to ballistic missiles like those fired Friday night.

Israel obliterated top Iranian nuclear scientists with incredible precision, according to stunning new photos showing single apartments blown out of Tehran high-rises. Aftermath pictures of the

Israel’s historic strike on Iran revealed years of Mossad activity inside the country, including hidden weapons, drones and assassinations of nuclear officials.

Israel has carried out a strike against Iran. The strike came hours after U.S. and Israeli officials had warned one was imminent. Follow along for live updates, news and analysis.

Follow the latest news after Israel launched strikes at Iran, a dramatic escalation in long-running tensions between the two countries.

The extent of the damage to Natanz remains unclear, but Tehran said there was no indication of pollution caused by nuclear materials in the area. The Israeli army also attacked a number of military sites and civilian infrastructure like power plants, in several provinces across the country.